[18F]-FDG PET/CT characterisation of progressive HIV-associated tuberculosis

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Title: [18F]-FDG PET/CT characterisation of progressive HIV-associated tuberculosis
Author(s): Wilkinson, RJ
Esmail, H
Lesosky, M
Lai, RP
Wilkinson, KA
Graham, CM
Coussens, AK
Oni, T
Warwick, J
Said-Hartley, Q
Koegenelburg, CF
Walzl, G
Flynn, JL
Young, DB
Barry, CE
O'Garra, A
Item Type: Journal Article
Abstract: Tuberculosis is classically divided into states of latent infection and active disease. Using combined positron emission and computed tomography in 35 asymptomatic, antiretroviral therapy naïve, HIV-1 infected adults with latent tuberculosis, we identified ten individuals with pulmonary abnormalities suggestive of subclinical, active disease who were significantly more likely to progress to clinical disease. Our findings challenge the conventional two-state paradigm and may aid future identification of biomarkers predictive of progression.
Date of Acceptance: 8-Jul-2016
URI: http://hdl.handle.net/10044/1/37409
ISSN: 1546-170X
Publisher: Nature Publishing Group
Journal / Book Title: Nature Medicine
Sponsor/Funder: Bill & Melinda Gates Foundation
Wellcome Trust
Wellcome Trust
Wellcome Trust
Funder's Grant Number: Grant Number 37882
077381/Z/05/Z
090170/Z/09/Z
104803/Z/14/ZR
Keywords: Immunology
11 Medical And Health Sciences
Publication Status: Accepted
Appears in Collections:Department of Medicine
Faculty of Medicine



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