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Novel Denisovan and Neanderthal Retroviruses

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Title: Novel Denisovan and Neanderthal Retroviruses
Author(s): Lee, A
Huntley, D
Aiewsakun, P
Kanda, RK
Lynn, C
Tristem, M
Item Type: Journal Article
Abstract: Following the recent availability of high-coverage genomes for Denisovan and Neanderthal hominids, we conducted a screen for endogenized retroviruses, identifying six novel, previously unreported HERV-K(HML2) elements (HERV-K is human endogenous retrovirus K). These elements are absent from the human genome (hg38) and appear to be unique to archaic hominids. These findings provide further evidence supporting the recent activity of the HERV-K(HML2) group, which has been implicated in human disease. They will also provide insights into the evolution of archaic hominids.
Publication Date: 20-Aug-2014
Date of Acceptance: 18-Aug-2014
URI: http://hdl.handle.net/10044/1/40137
DOI: http://dx.doi.org/10.1128/JVI.01825-14
ISSN: 1098-5514
Publisher: American Society for Microbiology
Start Page: 12907
End Page: 12909
Journal / Book Title: Journal of Virology
Volume: 88
Issue: 21
Copyright Statement: © 2014 Lee et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license.
Keywords: Science & Technology
Life Sciences & Biomedicine
Virology
GENOME SEQUENCE
Animals
Endogenous Retroviruses
Female
Fossils
Genome
Hominidae
Animals
Hominidae
Endogenous Retroviruses
Genome
Fossils
Female
Virology
06 Biological Sciences
07 Agricultural And Veterinary Sciences
11 Medical And Health Sciences
Publication Status: Published
Appears in Collections:Faculty of Natural Sciences



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