A review of the role of Neurotensin and its receptors in colorectal cancer

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Title: A review of the role of Neurotensin and its receptors in colorectal cancer
Author(s): Qiu, SY
Pellino, G
Fiorentino, F
Rasheed, S
Darzi, A
Tekkis, P
Kontovounisios, C
Item Type: Journal Article
Abstract: Neurotensin (NTS) is a physiologically occurring hormone which affects the function of the gastrointestinal (GI) tract. In recent years, NTS, acting through its cellular receptors (NTSR), has been implicated in the carcinogenesis of several cancers. In colorectal cancer (CRC), a significant body of evidence, from in vitro and in vivo studies, is available which elucidates the molecular biology of NTS/NTSR signalling and the resultant growth of CRC cells. There is growing clinical data from human studies which corroborate the role NTS/NTSR plays in the development of human CRC. Furthermore, blockade and modulation of the NTS/NTSR signalling pathways appears to reduce CRC growth in cell cultures and animal studies. Lastly, NTS/NTSR also shows potential of being utilized as a diagnostic biomarker for cancers as well as targets for functional imaging. We summarize the existing evidence and understanding of the role of NTS and its receptors in CRC.
Publication Date: 31-Dec-2017
Date of Acceptance: 24-Jan-2017
URI: http://hdl.handle.net/10044/1/44236
ISSN: 1687-630X
Publisher: Hindawi Publishing Corporation
Journal / Book Title: Gastroenterology Research and Practice
Copyright Statement: This paper is embargoed until publication. Once published will be available fully open access.
Publication Status: Accepted
Embargo Date: publication subject to indefinite embargo
Appears in Collections:Division of Surgery
Faculty of Medicine



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