Meeting report: risk assessment of tamiflu use under pandemic conditions.

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Title: Meeting report: risk assessment of tamiflu use under pandemic conditions.
Authors: Singer, AC
Howard, BM
Johnson, AC
Knowles, CJ
Jackman, S
Accinelli, C
Caracciolo, AB
Bernard, I
Bird, S
Boucard, T
Boxall, A
Brian, JV
Cartmell, E
Chubb, C
Churchley, J
Costigan, S
Crane, M
Dempsey, MJ
Dorrington, B
Ellor, B
Fick, J
Holmes, J
Hutchinson, T
Karcher, F
Kelleher, SL
Marsden, P
Noone, G
Nunn, MA
Oxford, J
Rachwal, T
Roberts, N
Roberts, M
Saccà, ML
Sanders, M
Straub, JO
Terry, A
Thomas, D
Toovey, S
Townsend, R
Voulvoulis, N
Watts, C
Item Type: Journal Article
Abstract: On 3 October 2007, 40 participants with diverse expertise attended the workshop Tamiflu and the Environment: Implications of Use under Pandemic Conditions to assess the potential human health impact and environmental hazards associated with use of Tamiflu during an influenza pandemic. Based on the identification and risk-ranking of knowledge gaps, the consensus was that oseltamivir ethylester-phosphate (OE-P) and oseltamivir carboxylate (OC) were unlikely to pose an ecotoxicologic hazard to freshwater organisms. OC in river water might hasten the generation of OC-resistance in wildfowl, but this possibility seems less likely than the potential disruption that could be posed by OC and other pharmaceuticals to the operation of sewage treatment plants. The work-group members agreed on the following research priorities: a) available data on the ecotoxicology of OE-P and OC should be published; b) risk should be assessed for OC-contaminated river water generating OC-resistant viruses in wildfowl; c) sewage treatment plant functioning due to microbial inhibition by neuraminidase inhibitors and other antimicrobials used during a pandemic should be investigated; and d) realistic worst-case exposure scenarios should be developed. Additional modeling would be useful to identify localized areas within river catchments that might be prone to high pharmaceutical concentrations in sewage treatment plant effluent. Ongoing seasonal use of Tamiflu in Japan offers opportunities for researchers to assess how much OC enters and persists in the aquatic environment.
Issue Date: 1-Nov-2008
URI: http://hdl.handle.net/10044/1/52764
DOI: https://dx.doi.org/10.1289/ehp.11310
ISSN: 0091-6765
Start Page: 1563
End Page: 1567
Journal / Book Title: Environmental Health Perspectives
Volume: 116
Issue: 11
Copyright Statement: © 2008 EHP. Reproduced with permission from Environmental Health Perspectives.
Keywords: Science & Technology
Life Sciences & Biomedicine
Environmental Sciences
Public, Environmental & Occupational Health
Toxicology
Environmental Sciences & Ecology
ENVIRONMENTAL SCIENCES
PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH, SCI
antiviral
drug
ecotoxicology
influenza
pandemic
pharmaceutical
pollution
sewage treatment plant
Tamiflu
NEURAMINIDASE INHIBITORS
INFLUENZA-VIRUSES
OSELTAMIVIR TREATMENT
RESISTANCE
SUSCEPTIBILITY
Humans
Influenza, Human
Oseltamivir
Risk Assessment
11 Medical And Health Sciences
05 Environmental Sciences
Notes: PMCID: PMC2592279
Conference Place: United States
Appears in Collections:Centre for Environmental Policy
Faculty of Natural Sciences



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