A common biological basis of obesity and nicotine addiction

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Title: A common biological basis of obesity and nicotine addiction
Author(s): Thorgeirsson, TE
Gudbjartsson, DF
Sulem, P
Besenbacher, S
Styrkarsdottir, U
Thorleifsson, G
Walters, GB
Furberg, H
Sullivan, PF
Marchini, J
McCarthy, MI
Steinthorsdottir, V
Thorsteinsdottir, U
Stefansson, K
Item Type: Journal Article
Abstract: Smoking influences body weight such that smokers weigh less than non-smokers and smoking cessation often leads to weight increase. The relationship between body weight and smoking is partly explained by the effect of nicotine on appetite and metabolism. However, the brain reward system is involved in the control of the intake of both food and tobacco. We evaluated the effect of single-nucleotide polymorphisms (SNPs) affecting body mass index (BMI) on smoking behavior, and tested the 32 SNPs identified in a meta-analysis for association with two smoking phenotypes, smoking initiation (SI) and the number of cigarettes smoked per day (CPD) in an Icelandic sample (N=34 216 smokers). Combined according to their effect on BMI, the SNPs correlate with both SI (r=0.019, P=0.00054) and CPD (r=0.032, P=8.0 × 10−7). These findings replicate in a second large data set (N=127 274, thereof 76 242 smokers) for both SI (P=1.2 × 10−5) and CPD (P=9.3 × 10−5). Notably, the variant most strongly associated with BMI (rs1558902-A in FTO) did not associate with smoking behavior. The association with smoking behavior is not due to the effect of the SNPs on BMI. Our results strongly point to a common biological basis of the regulation of our appetite for tobacco and food, and thus the vulnerability to nicotine addiction and obesity.
Publication Date: 1-Oct-2013
Date of Acceptance: 22-Jul-2013
URI: http://hdl.handle.net/10044/1/53985
DOI: https://dx.doi.org/10.1038/tp.2013.81
ISSN: 2158-3188
Publisher: Nature Publishing Group
Journal / Book Title: Translational Psychiatry
Volume: 3
Copyright Statement: © 2013 Macmillan Publishers Limited All rights reserved. This work is licensed under a Creative Commons Attribution- NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
Keywords: Science & Technology
Life Sciences & Biomedicine
Psychiatry
addiction
body mass index
nicotine dependence
obesity
smoking
BODY-MASS INDEX
SMOKING-BEHAVIOR
FOOD-INTAKE
DSM-V
ASSOCIATION
LOCI
POPULATION
DEPENDENCE
VARIANTS
CANCER
Age of Onset
Behavior, Addictive
Body Mass Index
Humans
Iceland
Obesity
Polymorphism, Single Nucleotide
Smoking
Tobacco Use Disorder
TAG Consortium
Oxford-GSK Consortium
ENGAGE consortium
Humans
Obesity
Tobacco Use Disorder
Body Mass Index
Smoking
Behavior, Addictive
Age of Onset
Polymorphism, Single Nucleotide
Iceland
Science & Technology
Life Sciences & Biomedicine
Psychiatry
addiction
body mass index
nicotine dependence
obesity
smoking
BODY-MASS INDEX
SMOKING-BEHAVIOR
FOOD-INTAKE
DSM-V
ASSOCIATION
LOCI
POPULATION
DEPENDENCE
VARIANTS
CANCER
Publication Status: Published
Article Number: ARTN e308
Appears in Collections:National Heart and Lung Institute
Department of Medicine
Faculty of Medicine
Epidemiology, Public Health and Primary Care



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