Altmetric

Analysis of cell size homeostasis at the single-cell and population level

File Description SizeFormat 
fphy-06-00064.pdfPublished version2.95 MBAdobe PDFView/Open
Title: Analysis of cell size homeostasis at the single-cell and population level
Authors: Thomas, P
Item Type: Journal Article
Abstract: Growth pervades all areas of life from single cells to cell populations to tissues. Cell size often fluctuates significantly from cell to cell and from generation to generation. Here we present a unified framework to predict the statistics of cell size variations within a lineage tree of a proliferating population. We analytically characterize (i) the distributions of cell size snapshots, (ii) the distribution within a population tree, and (iii) the distribution of lineages across the tree. Surprisingly, these size distributions differ significantly from observing single cells in isolation. In populations, cells seemingly grow to different sizes, typically exhibit less cell-to-cell variability and often display qualitatively different sensitivities to cell cycle noise and division errors. We demonstrate the key findings using recent single-cell data and elaborate on the implications for the ability of cells to maintain a narrow size distribution and the emergence of different power laws in these distributions.
Issue Date: 26-Jun-2018
Date of Acceptance: 4-Jun-2018
URI: http://hdl.handle.net/10044/1/60937
DOI: https://dx.doi.org/10.3389/fphy.2018.00064
ISSN: 2296-424X
Publisher: Frontiers Media
Journal / Book Title: Frontiers in Physics
Volume: 6
Copyright Statement: Growth pervades all areas of life from single cells to cell populations to tissues. Cell size often fluctuates significantly from cell to cell and from generation to generation. Here we present a unified framework to predict the statistics of cell size variations within a lineage tree of a proliferating population. We analytically characterize (i) the distributions of cell size snapshots, (ii) the distribution within a population tree, and (iii) the distribution of lineages across the tree. Surprisingly, these size distributions differ significantly from observing single cells in isolation. In populations, cells seemingly grow to different sizes, typically exhibit less cell-to-cell variability and often display qualitatively different sensitivities to cell cycle noise and division errors. We demonstrate the key findings using recent single-cell data and elaborate on the implications for the ability of cells to maintain a narrow size distribution and the emergence of different power laws in these distributions.
Sponsor/Funder: Royal Commission for the Exhibition of 1851
Publication Status: Published
Article Number: ARTN 64
Appears in Collections:Mathematics
Applied Mathematics and Mathematical Physics
Faculty of Natural Sciences



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Creative Commons