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Slice-illuminated optical projection tomography

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Title: Slice-illuminated optical projection tomography
Authors: French, P
Davis, S
Wisniewski, L
Kumar, S
Correia, T
Arridge, S
Frankel, P
McGinty, J
Item Type: Journal Article
Abstract: To improve the imaging performance of optical projection tomography (OPT) in live samples, we have explored a parallelized implementation of semi-confocal line illumination and detection to discriminate against scattered photons. Slice-illuminated OPT (sl-OPT) improves reconstruction quality in scattering samples by reducing interpixel crosstalk at the cost of increased acquisition time. For in vivo imaging, this can be ameliorated through the use of compressed sensing on angularly undersampled OPT data sets. Here, we demonstrate sl-OPT applied to 3D imaging of bead phantoms and live adult zebrafish.
Issue Date: 15-Nov-2018
Date of Acceptance: 1-Oct-2018
URI: http://hdl.handle.net/10044/1/65197
DOI: https://dx.doi.org/10.1364/OL.43.005555
ISSN: 0146-9592
Publisher: Optical Society of America
Start Page: 5555
End Page: 5558
Journal / Book Title: Optics Letters
Volume: 43
Issue: 22
Copyright Statement: © 2018 Optical Society of America. Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI.
Sponsor/Funder: Medical Research Council (MRC)
Funder's Grant Number: MR/K011561/1
Keywords: Science & Technology
Physical Sciences
0205 Optical Physics
0206 Quantum Physics
0906 Electrical And Electronic Engineering
Publication Status: Published
Appears in Collections:Physics
Faculty of Natural Sciences