3-D printing of chitosan-calcium phosphate inks: rheology, interactions and characterization

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Title: 3-D printing of chitosan-calcium phosphate inks: rheology, interactions and characterization
Authors: Caballero, SSR
Saiz, E
Montembault, A
Tadier, S
Maire, E
David, L
Delair, T
Gremillard, L
Item Type: Journal Article
Abstract: Bone substitute fabrication is of interest to meet the worldwide incidence of bone disorders. Physical chitosan hydrogels with intertwined apatite particles were chosen to meet the bio-physical and mechanical properties required by a potential bone substitute. A set up for 3-D printing by robocasting was found adequate to fabricate scaffolds. Inks consisted of suspensions of calcium phosphate particles in chitosan acidic aqueous solution. The inks are shear-thinning and consist of a suspension of dispersed platelet aggregates of dicalcium phosphate dihydrate in a continuous chitosan phase. The rheological properties of the inks were studied, including their shear-thinning characteristics and yield stress. Scaffolds were printed in basic water/ethanol baths to induce transformation of chitosan-calcium phosphates suspension into physical hydrogel of chitosan mineralized with apatite. Scaffolds consisted of a chitosan polymeric matrix intertwined with poorly crystalline apatite particles. Results indicate that ink rheological properties could be tuned by controlling ink composition: in particular, more printable inks are obtained with higher chitosan concentration (0.19 mol·L−1).
Issue Date: 1-Jan-2019
Date of Acceptance: 4-Dec-2018
URI: http://hdl.handle.net/10044/1/66378
DOI: https://dx.doi.org/10.1007/s10856-018-6201-y
ISSN: 0957-4530
Publisher: Springer Verlag
Journal / Book Title: Journal of Materials Science: Materials in Medicine
Volume: 30
Issue: 1
Copyright Statement: © 2018 Springer Science+Business Media, LLC, part of Springer Nature. The final publication is available at Springer via https://dx.doi.org/10.1007/s10856-018-6201-y.
Keywords: Science & Technology
Engineering, Biomedical
Materials Science, Biomaterials
Materials Science
0903 Biomedical Engineering
0912 Materials Engineering
Biomedical Engineering
Publication Status: Published
Article Number: 6
Online Publication Date: 2018-12-29
Appears in Collections:Faculty of Engineering

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