Fiber-integrated Brillouin microspectroscopy: towards Brillouin endoscopy

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Title: Fiber-integrated Brillouin microspectroscopy: towards Brillouin endoscopy
Authors: Kabakova, IV
Xiang, Y
Paterson, C
Torok, P
Item Type: Journal Article
Abstract: Brillouin imaging (BI) for micromechanical characterization of tissues and biomaterials is a fast-developing field of research with a strong potential for medical diagnosis of disease-modified tissues and cells. Although the principles of BI imply its compatibility with in vivo and in situ measurements, the integration of BI with a flexible catheter, capable of reaching the region of interest within the body, is yet to be reported. Here, for the first time, we experimentally investigate integration of the Brillouin spectroscope with standard optical fiber components to achieve a Brillouin endoscope. The performance of single-fiber and dual-fiber endoscopes are demonstrated and analyzed. We show that a major challenge in construction of Brillouin endoscopes is the strong backward Brillouin scattering in the optical fiber and we present a dual-fiber geometry as a possible solution. Measurements of Brillouin spectra in test liquids (water, ethanol and glycerol) are demonstrated using the dual-fiber endoscope and its performance is analyzed numerically with the help of a beam propagation model.
Issue Date: 1-Nov-2017
Date of Acceptance: 18-Aug-2017
URI: http://hdl.handle.net/10044/1/69812
DOI: https://dx.doi.org/10.1142/S1793545817420020
ISSN: 1793-5458
Publisher: World Scientific Publishing
Journal / Book Title: Journal of Innovative Optical Health Sciences
Volume: 10
Issue: 6
Copyright Statement: © The Author(s). This is an Open Access article published by World Scienti ̄c Publishing Company. It is distributed under the terms of the CreativeCommons Attribution 4.0 (CC-BY) License. Further distribution of this work is permitted, provided the original work is properlycited.
Sponsor/Funder: Renishaw Plc
Commission of the European Communities
National Physical Laboratory
Engineering & Physical Science Research Council (EPSRC)
Engineering & Physical Science Research Council (EPSRC)
Engineering & Physical Science Research Council (EPSRC)
Commission of the European Communities
Wellcome Trust
Commission of the European Communities
Engineering & Physical Science Research Council (EPSRC)
Engineering & Physical Science Research Council (EPSRC)
Engineering & Physical Science Research Council (EPSRC)
Engineering & Physical Science Research Council (EPSRC)
Imperial College Trust
The Royal Society
Biotechnology and Biological Sciences Research Cou
Funder's Grant Number: n/a
IST-2000-26479
NPL321673
GR/R92349/01
GR/S25975/01
EP/C528905/1
NMP3-CT-2007-033310
084835/Z/08/Z
224226
EP/H500227/1
n/a
N/A
N/A
P46596
UF150335
BB/N021576/1
Keywords: Science & Technology
Physical Sciences
Life Sciences & Biomedicine
Optics
Radiology, Nuclear Medicine & Medical Imaging
Brillouin imaging
fiber integration
endoscope
OPTICAL MICROSCOPY
SPECTROMETER
SCATTERING
COLLAGEN
LASER
LENS
Publication Status: Published
Article Number: ARTN 1742002
Online Publication Date: 2017-09-13
Appears in Collections:Physics
Photonics



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