A role for Dicer in immune regulation

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Title: A role for Dicer in immune regulation
Authors: Cobb, BS
Hertweck, A
Smith, J
O'Connor, E
Graf, D
Cook, T
Smale, ST
Sakaguchi, S
Livesey, FJ
Fisher, AG
Merkenschlager, M
Item Type: Journal Article
Abstract: Micro RNAs (miRNAs) regulate gene expression at the posttranscriptional level. Here we show that regulatory T (T reg) cells have a miRNA profile distinct from conventional CD4 T cells. A partial T reg cell-like miRNA profile is conferred by the enforced expression of Foxp3 and, surprisingly, by the activation of conventional CD4 T cells. Depleting miRNAs by eliminating Dicer, the RNAse III enzyme that generates functional miRNAs, reduces T reg cell numbers and results in immune pathology. Dicer facilitates, in a cell-autonomous fashion, the development of T reg cells in the thymus and the efficient induction of Foxp3 by transforming growth factor beta. These results suggest that T reg cell development involves Dicer-generated RNAs.
Issue Date: 23-Oct-2006
Date of Acceptance: 25-Sep-2006
URI: http://hdl.handle.net/10044/1/71593
DOI: https://doi.org/10.1084/jem.20061692
ISSN: 0022-1007
Publisher: Rockefeller University Press
Start Page: 2519
End Page: 2527
Journal / Book Title: Journal of Experimental Medicine
Volume: 203
Issue: 11
Copyright Statement: © 2006 Rockefeller University Press.
Sponsor/Funder: Medical Research Council (MRC)
Funder's Grant Number: PO4050659629
Keywords: Science & Technology
Life Sciences & Biomedicine
Immunology
Medicine, Research & Experimental
Research & Experimental Medicine
TRANSCRIPTION FACTOR FOXP3
T-CELL DEVELOPMENT
MICROPROCESSOR COMPLEX
LINEAGE CHOICE
TGF-BETA
MICRORNAS
DIFFERENTIATION
TARGETS
MOUSE
INDUCTION
Animals
Cell Differentiation
Cells, Cultured
Forkhead Transcription Factors
Mice
MicroRNAs
Ribonuclease III
T-Lymphocytes, Regulatory
Thymus Gland
Transforming Growth Factor beta
Thymus Gland
Cells, Cultured
Animals
Mice
Ribonuclease III
Transforming Growth Factor beta
MicroRNAs
Cell Differentiation
T-Lymphocytes, Regulatory
Forkhead Transcription Factors
11 Medical and Health Sciences
Immunology
Conference Place: United States
Online Publication Date: 2006-10-23
Appears in Collections:Clinical Sciences
Molecular Sciences
Department of Medicine
Faculty of Medicine



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