N-cadherin orchestrates self-organization of neurons within a columnar unit in the drosophila medulla

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Title: N-cadherin orchestrates self-organization of neurons within a columnar unit in the drosophila medulla
Authors: Trush, O
Liu, C
Han, X
Nakai, Y
Takayama, R
Murakawa, H
Carrillo, JA
Takechi, H
Hakeda-Suzuki, S
Suzuki, T
Sato, M
Item Type: Journal Article
Abstract: Columnar structure is a basic unit of the brain, but the mechanism underlying its development remains largely unknown. The medulla, the largest ganglion of the Drosophila melanogaster visual center, provides a unique opportunity to reveal the mechanisms of 3D organization of the columns. In this study, using N-cadherin (Ncad) as a marker, we reveal the donut-like columnar structures along the 2D layer in the larval medulla that evolves to form three distinct layers in pupal development. Column formation is initiated by three core neurons, R8, R7, and Mi1, which establish distinct concentric domains within a column. We demonstrate that Ncad-dependent relative adhesiveness of the core columnar neurons regulates their relative location within a column along a 2D layer in the larval medulla according to the differential adhesion hypothesis. We also propose the presence of mutual interactions among the three layers during formation of the 3D structures of the medulla columns.
Issue Date: 24-Jul-2019
Date of Acceptance: 15-May-2019
URI: http://hdl.handle.net/10044/1/73087
DOI: https://doi.org/10.1523/JNEUROSCI.3107-18.2019
ISSN: 0270-6474
Publisher: Society for Neuroscience
Start Page: 5861
End Page: 5880
Journal / Book Title: Journal of Neuroscience
Volume: 39
Issue: 30
Copyright Statement: © 2019 the authors.
Sponsor/Funder: The Royal Society
Engineering & Physical Science Research Council (EPSRC)
Funder's Grant Number: WM120001
EP/P031587/1
Keywords: Science & Technology
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
columnar unit
differential adhesion
Drosophila
N-cadherin
optic lobe
visual system
VISUAL-SYSTEM
DN-CADHERIN
ADHESION
EXPRESSION
SPECIFICATION
RECEPTOR
AXON
DIFFERENTIATION
SELECTION
CIRCUITS
Drosophila
N-cadherin
columnar unit
differential adhesion
optic lobe
visual system
Science & Technology
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
columnar unit
differential adhesion
Drosophila
N-cadherin
optic lobe
visual system
VISUAL-SYSTEM
DN-CADHERIN
ADHESION
EXPRESSION
SPECIFICATION
RECEPTOR
AXON
DIFFERENTIATION
SELECTION
CIRCUITS
11 Medical and Health Sciences
17 Psychology and Cognitive Sciences
Neurology & Neurosurgery
Publication Status: Published
Embargo Date: 2020-01-24
Online Publication Date: 2019-07-24
Appears in Collections:Mathematics
Applied Mathematics and Mathematical Physics
Faculty of Natural Sciences



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